Preclinical Efficacy Failure of Human CNS-Derived Stem Cells for Use in the Pathway Study of Cervical Spinal Cord Injury

Preclinical Efficacy Failure of Human CNS-Derived Stem Cells for Use in the Pathway Study of Cervical Spinal Cord Injury

We previously showed the efficacy of multiple research cell lines (RCLs) of human CNS neural stem cells (HuCNS-SCs) in mouse and rat models of thoracic spinal cord injury (SCI), supporting a thoracic SCI clinical trial. Experts recommend in vivo preclinical testing of the intended clinical cell lot/...

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Bibliographic Details
Main Authors:	Aileen J. Anderson, Katja M. Piltti, Mitra J. Hooshmand, Rebecca A. Nishi, Brian J. Cummings
Format:	Article
Language:	English
Published:	Elsevier 2017-02-01
Series:	Stem Cell Reports
Subjects:	human neural stem cells (hNSC) spinal cord injury (SCI) cervical efficacy good manufacturing practices (GMP) RIGOR FDA guidelines for cell therapies
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213671116303083

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