Fundamental CRISPR-Cas9 tools and current applications in microbial systems

Fundamental CRISPR-Cas9 tools and current applications in microbial systems

Derived from the bacterial adaptive immune system, CRISPR technology has revolutionized conventional genetic engineering methods and unprecedentedly facilitated strain engineering. In this review, we outline the fundamental CRISPR tools that have been employed for strain optimization. These tools in...

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Bibliographic Details
Main Authors: Pingfang Tian, Jia Wang, Xiaolin Shen, Justin Forrest Rey, Qipeng Yuan, Yajun Yan
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2017-09-01
Series:Synthetic and Systems Biotechnology
Subjects:
CRISPR-Cas9
CRISPR interference
CRISPR activation
DNA repair
Homologous recombination
Online Access:http://www.sciencedirect.com/science/article/pii/S2405805X17300108

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