BCGiosis as a presenting feature of a child with chronic granulomatous disease

• Main Authors: Zahra Movahedi, Sayna Norouzi, Setareh Mamishi, Nima Rezaei
• Format: Article
• Language: English
• Published: Elsevier
• Series: Brazilian Journal of Infectious Diseases
• Subjects: BCG vaccine; Mycobacterium bovis; granulomatous disease; chronic
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000100016&lng=en&tlng=en

Bacillus Calmette Guerin (BCG) vaccine, which is administered to all newborns in some regions, could lead to serious complication ranging from local disease (known as BCGitis) to disseminated disease (BCGosis) in a group of patients with primary immunodeficiency diseases. We are reporting here a 3.5 year-old girl with a history of prolonged BCGitis, which developed to disseminated disease without any other special features. Immunological studies with nitro-blue tetrazolium test confirmed the diagnosis of chronic granulomatous disease in this patient. Chronic granulomatous disease should be considered in the list of differential diagnosis in all children with BCGosis, even in the absence of any other manifestations related to immunodeficiency.