The human SKA complex drives the metaphase-anaphase cell cycle transition by recruiting protein phosphatase 1 to kinetochores

The human SKA complex drives the metaphase-anaphase cell cycle transition by recruiting protein phosphatase 1 to kinetochores

The spindle- and kinetochore-associated (Ska) complex is essential for normal anaphase onset in mitosis. The C-terminal domain (CTD) of Ska1 binds microtubules and was proposed to facilitate kinetochore movement on depolymerizing spindle microtubules. Here, we show that Ska complex recruits protein...

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Bibliographic Details
Main Authors: Sushama Sivakumar, Paweł Ł Janczyk, Qianhui Qu, Chad A Brautigam, P Todd Stukenberg, Hongtao Yu, Gary J Gorbsky
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-03-01
Series:eLife
Subjects:
microtubule
spindle checkpoint
mitosis
mps1
anaphase promoting complex/cyclosome
phosphatase
Online Access:https://elifesciences.org/articles/12902

Internet

https://elifesciences.org/articles/12902

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