EpCAM-Mediated Cellular Plasticity Promotes Radiation Resistance and Metastasis in Breast Cancer

EpCAM-Mediated Cellular Plasticity Promotes Radiation Resistance and Metastasis in Breast Cancer

Substantial number of breast cancer (BC) patients undergoing radiation therapy (RT) develop local recurrence over time. During RT therapy, cells can gradually acquire resistance implying adaptive radioresistance. Here we probe the mechanisms underlying this acquired resistance by first establishing...

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Bibliographic Details
Main Authors: Arijit Mal, Amirali B. Bukhari, Ram K. Singh, Aastha Kapoor, Amlan Barai, Ishan Deshpande, Tabassum Wadasadawala, Pritha Ray, Shamik Sen, Abhijit De
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
EpCAM
breast cancer
radiation resistance
cancer stem cell
metastasis
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.597673/full

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