Synergistic roles of p53 and HIF1α in human renal cell carcinoma-cell apoptosis responding to the inhibition of mTOR and MDM2 signaling pathways
Qing-jun Liu,* Hong-liang Shen,* Jun Lin, Xiu-hong Xu, Zheng-guo Ji, Xiao Han, Dong-hao Shang, Pei-qian YangDepartment of Urology Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China*These authors contributed equally to this workInt...
Main Authors: | Liu QJ, Shen HL, Lin J, Xu XH, Ji ZG, Han X, Shang DH, Yang PQ |
---|---|
Format: | Article |
Language: | English |
Published: |
Dove Medical Press
2016-02-01
|
Series: | Drug Design, Development and Therapy |
Subjects: | |
Online Access: | https://www.dovepress.com/synergistic-roles-of-p53-and-hif1alpha-in-human-renal-cell-carcinoma-c-peer-reviewed-article-DDDT |
Similar Items
-
Vandetanib (ZD6474) induces antiangiogenesis through mTOR–HIF-1 alpha–VEGF signaling axis in breast cancer cells
by: Li L, et al.
Published: (2018-11-01) -
Blocking Mammalian Target of Rapamycin (mTOR) Attenuates HIF-1α Pathways Engaged-Vascular Endothelial Growth Factor (VEGF) in Diabetic Retinopathy
by: Jie Wei, et al.
Published: (2016-12-01) -
Cortisol inhibits mTOR signaling in avascular necrosis of the femoral head
by: Yun Liao, et al.
Published: (2017-10-01) -
CCI-779 Inhibits Rhabdomyosarcoma Xenograft Growth by an Antiangiogenic Mechanism Linked to the Targeting of mTOR/Hif-1α/VEGF Signaling
by: Xiaolin Wan, et al.
Published: (2006-05-01) -
Antitumor effects of low‐dose tipifarnib on the mTOR signaling pathway and reactive oxygen species production in HIF‐1α‐expressing gastric cancer cells
by: Noriyuki Egawa, et al.
Published: (2021-05-01)