How Microglia Manages Non-cell Autonomous Vicious Cycling of Aβ Toxicity in the Pathogenesis of AD
Alzheimer’s disease (AD) is a progressive neurodegenerative disease and a common form of dementia that affects cognition and memory mostly in aged people. AD pathology is characterized by the accumulation of β-amyloid (Aβ) senile plaques and the neurofibrillary tangles of phosphorylated tau, resulti...
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Frontiers Media S.A.
2020-11-01
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| Series: | Frontiers in Molecular Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnmol.2020.593724/full |
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doaj-b9da2a0b913f44fc9fde8871fcbfa1e82020-11-25T04:09:09ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992020-11-011310.3389/fnmol.2020.593724593724How Microglia Manages Non-cell Autonomous Vicious Cycling of Aβ Toxicity in the Pathogenesis of ADYunHee Seol0Soomin Ki1Hannah L. Ryu2Sooyoung Chung3Junghee Lee4Junghee Lee5Hoon Ryu6Hoon Ryu7Center for Neuroscience, Brain Science Institute, Korea Institute of Science and Technology, Seoul, South KoreaDepartment of Brain and Cognitive Science, Ewha Womens University, Seoul, South KoreaDepartment of Neurology, Boston University Alzheimer’s Disease Center, Boston University School of Medicine, Boston, MA, United StatesCenter for Neuroscience, Brain Science Institute, Korea Institute of Science and Technology, Seoul, South KoreaDepartment of Neurology, Boston University Alzheimer’s Disease Center, Boston University School of Medicine, Boston, MA, United StatesVA Boston Healthcare System, Boston, MA, United StatesCenter for Neuroscience, Brain Science Institute, Korea Institute of Science and Technology, Seoul, South KoreaDepartment of Neurology, Boston University Alzheimer’s Disease Center, Boston University School of Medicine, Boston, MA, United StatesAlzheimer’s disease (AD) is a progressive neurodegenerative disease and a common form of dementia that affects cognition and memory mostly in aged people. AD pathology is characterized by the accumulation of β-amyloid (Aβ) senile plaques and the neurofibrillary tangles of phosphorylated tau, resulting in cell damage and neurodegeneration. The extracellular deposition of Aβ is regarded as an important pathological marker and a principal-agent of neurodegeneration. However, the exact mechanism of Aβ-mediated pathogenesis is not fully understood yet. Recently, a growing body of evidence provides novel insights on the major role of microglia and its non-cell-autonomous cycling of Aβ toxicity. Hence, this article provides a comprehensive overview of microglia as a significant player in uncovering the underlying disease mechanisms of AD.https://www.frontiersin.org/articles/10.3389/fnmol.2020.593724/fullAlzheimer’s diseasemicrogliaamyloid-βnon-cell-autonomous toxicityvicious cycle |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
YunHee Seol Soomin Ki Hannah L. Ryu Sooyoung Chung Junghee Lee Junghee Lee Hoon Ryu Hoon Ryu |
| spellingShingle |
YunHee Seol Soomin Ki Hannah L. Ryu Sooyoung Chung Junghee Lee Junghee Lee Hoon Ryu Hoon Ryu How Microglia Manages Non-cell Autonomous Vicious Cycling of Aβ Toxicity in the Pathogenesis of AD Frontiers in Molecular Neuroscience Alzheimer’s disease microglia amyloid-β non-cell-autonomous toxicity vicious cycle |
| author_facet |
YunHee Seol Soomin Ki Hannah L. Ryu Sooyoung Chung Junghee Lee Junghee Lee Hoon Ryu Hoon Ryu |
| author_sort |
YunHee Seol |
| title |
How Microglia Manages Non-cell Autonomous Vicious Cycling of Aβ Toxicity in the Pathogenesis of AD |
| title_short |
How Microglia Manages Non-cell Autonomous Vicious Cycling of Aβ Toxicity in the Pathogenesis of AD |
| title_full |
How Microglia Manages Non-cell Autonomous Vicious Cycling of Aβ Toxicity in the Pathogenesis of AD |
| title_fullStr |
How Microglia Manages Non-cell Autonomous Vicious Cycling of Aβ Toxicity in the Pathogenesis of AD |
| title_full_unstemmed |
How Microglia Manages Non-cell Autonomous Vicious Cycling of Aβ Toxicity in the Pathogenesis of AD |
| title_sort |
how microglia manages non-cell autonomous vicious cycling of aβ toxicity in the pathogenesis of ad |
| publisher |
Frontiers Media S.A. |
| series |
Frontiers in Molecular Neuroscience |
| issn |
1662-5099 |
| publishDate |
2020-11-01 |
| description |
Alzheimer’s disease (AD) is a progressive neurodegenerative disease and a common form of dementia that affects cognition and memory mostly in aged people. AD pathology is characterized by the accumulation of β-amyloid (Aβ) senile plaques and the neurofibrillary tangles of phosphorylated tau, resulting in cell damage and neurodegeneration. The extracellular deposition of Aβ is regarded as an important pathological marker and a principal-agent of neurodegeneration. However, the exact mechanism of Aβ-mediated pathogenesis is not fully understood yet. Recently, a growing body of evidence provides novel insights on the major role of microglia and its non-cell-autonomous cycling of Aβ toxicity. Hence, this article provides a comprehensive overview of microglia as a significant player in uncovering the underlying disease mechanisms of AD. |
| topic |
Alzheimer’s disease microglia amyloid-β non-cell-autonomous toxicity vicious cycle |
| url |
https://www.frontiersin.org/articles/10.3389/fnmol.2020.593724/full |
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