Influence of Angiopoietin Treatment with Hypoxia and Normoxia on Human Intervertebral Disc Progenitor Cell’s Proliferation, Metabolic Activity, and Phenotype

Influence of Angiopoietin Treatment with Hypoxia and Normoxia on Human Intervertebral Disc Progenitor Cell’s Proliferation, Metabolic Activity, and Phenotype

Increasing evidence implicates intervertebral disc (IVD) degeneration as a major contributor to low back pain. In addition to a series of pathogenic processes, degenerated IVDs become vascularized in contrast to healthy IVDs. In this context, angiopoietin (Ang) plays a crucial role and is involved i...

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Bibliographic Details
Main Authors: Muriel C. Bischof, Sonja Häckel, Andrea Oberli, Andreas S. Croft, Katharina A. C. Oswald, Christoph E. Albers, Benjamin Gantenbein, Julien Guerrero
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Applied Sciences
Subjects:
intervertebral disc (IVD)
nucleus pulposus progenitor cells (NPPCs)
angiopoietin-1 receptor (also known as Tie2)
fluorescence-activated cell sorting
hypoxia
normoxia
Online Access:https://www.mdpi.com/2076-3417/11/15/7144

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