Hyperosmolarity-induced AQP5 upregulation promotes inflammation and cell death via JNK1/2 Activation in human corneal epithelial cells

Hyperosmolarity-induced AQP5 upregulation promotes inflammation and cell death via JNK1/2 Activation in human corneal epithelial cells

Abstract Tear film hyperosmolarity and anterior ocular inflammation are two clinical signs that may be indicative of dry eye disease (DED). This condition can cause pathological and functional changes to the anterior ocular surface tissues. A contributing factor may be dysfunctional aquaporin 5 (AQP...

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Bibliographic Details
Main Authors: Yueping Ren, Huihui Lu, Peter S. Reinach, Qinxiang Zheng, Jinyang Li, Qiufan Tan, Hanlei Zhu, Wei Chen
Format: Article
Language:English
Published: Nature Publishing Group 2017-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-05145-y

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https://doi.org/10.1038/s41598-017-05145-y

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