Sorafenib, a systemic therapy for hepatocellular carcinoma

Sorafenib, a systemic therapy for hepatocellular carcinoma

Hepatocellular carcinoma is a lethal disease that requires a multidisciplinary approach and management. Surgical therapy offers long-term survival; however, few patients are candidates. There has been no accepted systemic therapy for this disease until recently. This article briefly discusses the ro...

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Bibliographic Details
Main Authors: Nahum Méndez-Sánchez;, Francisco Vásquez-Fernández;, Daniel Zamora-Valdés;, Misael Uribe
Format: Article
Language:English
Published: Elsevier 2008-01-01
Series:Annals of Hepatology
Subjects:
Liver cancer
hepatocellular carcinoma
HCV
HBV
sorafenib
Online Access:http://www.sciencedirect.com/science/article/pii/S1665268119318861
Description
Summary:Hepatocellular carcinoma is a lethal disease that requires a multidisciplinary approach and management. Surgical therapy offers long-term survival; however, few patients are candidates. There has been no accepted systemic therapy for this disease until recently. This article briefly discusses the role of RAS/RAF/MEK/ ERK signaling pathway in the pathogenesis of the disease and the promising role of sorafenib for advanced disease.
ISSN:1665-2681

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