| Summary: | Antibacterial compounds are generally produced from many herbal ingredients, but antibacterials may be produced from soil microbes, one of which is Actinomycetes. Actinomycetes are a soil bacterium capable of producing secondary metabolites in the form of antibacterial compounds. The antibacterial compound has the potential as an alternative antibacterial agent against oral microbes. One of the oral microbes that have a major role in the occurrence of caries is Streptococcus mutans and Lactobacillus acidophilus. This study aimed to analyze the antibacterial activity of Actinomycetes against the growth of S. mutans and L. acidophilus Actinomycetes extracts at the concentration of 0.625%, 1.25%, 2.5%, 5%, 10%, 20%, and 40% were respectively exerted as the treatment groups while 0.12% Chlorhexidine Gluconate (CHX) and aquadest as control. The measurement of antibacterial activity is done by looking at MIC and MBC. One Way ANOVA and Post Hoc Dunnets T3 test MIC and MBC values show p=0,000 (p <0.05). Actinomycetes extract at the concentration of 0.625% was able to inhibit the growth of S. mutans and L. acidophilus which was determined as the MIC and at the concentration of 40% as MBC of S.mutans and the concentration of 10% as MBC of L. acidophilus. There was an antibacterial activity of Actinomycetes to the growth of S. mutans and L.acidophilus.
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