A Cell for the Ages: Human γδ T Cells across the Lifespan
The complexity of the human immune system is exacerbated by age-related changes to immune cell functionality. Many of these age-related effects remain undescribed or driven by mechanisms that are poorly understood. γδ T cells, while considered an adaptive subset based on immunological ontogeny, reta...
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MDPI AG
2020-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/23/8903 |
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doaj-b9c2a4dce0af41568a7978551184c9792020-11-27T07:55:23ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-11-01218903890310.3390/ijms21238903A Cell for the Ages: Human γδ T Cells across the LifespanBrandi L. Clark0Paul G. Thomas1Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USADepartment of Immunology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USAThe complexity of the human immune system is exacerbated by age-related changes to immune cell functionality. Many of these age-related effects remain undescribed or driven by mechanisms that are poorly understood. γδ T cells, while considered an adaptive subset based on immunological ontogeny, retain both innate-like and adaptive-like characteristics. This T cell population is small but mighty, and has been implicated in both homeostatic and disease-induced immunity within tissues and throughout the periphery. In this review, we outline what is known about the effect of age on human peripheral γδ T cells, and call attention to areas of the field where further research is needed.https://www.mdpi.com/1422-0067/21/23/8903γδ T cellshumandevelopmentageperipherypassive immunity |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Brandi L. Clark Paul G. Thomas |
| spellingShingle |
Brandi L. Clark Paul G. Thomas A Cell for the Ages: Human γδ T Cells across the Lifespan International Journal of Molecular Sciences γδ T cells human development age periphery passive immunity |
| author_facet |
Brandi L. Clark Paul G. Thomas |
| author_sort |
Brandi L. Clark |
| title |
A Cell for the Ages: Human γδ T Cells across the Lifespan |
| title_short |
A Cell for the Ages: Human γδ T Cells across the Lifespan |
| title_full |
A Cell for the Ages: Human γδ T Cells across the Lifespan |
| title_fullStr |
A Cell for the Ages: Human γδ T Cells across the Lifespan |
| title_full_unstemmed |
A Cell for the Ages: Human γδ T Cells across the Lifespan |
| title_sort |
cell for the ages: human γδ t cells across the lifespan |
| publisher |
MDPI AG |
| series |
International Journal of Molecular Sciences |
| issn |
1661-6596 1422-0067 |
| publishDate |
2020-11-01 |
| description |
The complexity of the human immune system is exacerbated by age-related changes to immune cell functionality. Many of these age-related effects remain undescribed or driven by mechanisms that are poorly understood. γδ T cells, while considered an adaptive subset based on immunological ontogeny, retain both innate-like and adaptive-like characteristics. This T cell population is small but mighty, and has been implicated in both homeostatic and disease-induced immunity within tissues and throughout the periphery. In this review, we outline what is known about the effect of age on human peripheral γδ T cells, and call attention to areas of the field where further research is needed. |
| topic |
γδ T cells human development age periphery passive immunity |
| url |
https://www.mdpi.com/1422-0067/21/23/8903 |
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