VEGF up-regulation by G93A superoxide dismutase and the role of malate–aspartate shuttle inhibition
A gain of interaction of the amyotrophic lateral sclerosis (ALS)-linked G93A-superoxide dismutase-1 (G93A-hSOD1) with cytosolic malate dehydrogenase (cytMDH), a key enzyme in the malate–aspartate shuttle, diverts neurons towards anaerobic metabolism. Changes in vascular endothelial growth factor (VE...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2010-03-01
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| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996109003477 |