Role of primary immunodeficiency states in the development of BCG osteitis in children

• Main Authors: I. I. Snegireva, K. E. Zatolochina, N. A. Ozeretskovsky
• Format: Article
• Language: Russian
• Published: Ministry of Health of the Russian Federation. Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products» 2018-02-01
• Series: Биопрепараты: Профилактика, диагностика, лечение
• Subjects: фармаконадзор вакцин; бцж-оститы; первичные иммунодефициты; vaccine pharmacovigilance; bcg osteitis; primary immunodeficiency
• Online Access: https://www.biopreparations.ru/jour/article/view/7

The article presents an analysis of 522 cases of complications after BCG vaccination, i.e. post-vaccinal osteomyelitis, based on pharmacovigilance data obtained between 2001 and 2012. A detailed study of ill children revealed no clinical manifestations (severe bacterial, viral or fungal infections, repeat bacterial infections of respiratory tract, paraproctitis, chronic eczema etc) suggesting primary or secondary immunodeficiency. All of the 135 children who were vaccinated with measles, mumps and rubella vaccine and all of the 315 children who were vaccinated with live polio vaccine had no complications in the post-vaccinal period.