Inhibitors of Human Dihydrofolate Reductase: A Computational Design and Docking Studies Using Glide

Inhibitors of Human Dihydrofolate Reductase: A Computational Design and Docking Studies Using Glide

Dihydrofolate reductase (DHFR) plays a vital role in the DNA synthesis by reducing dihydrofolic acid to tetrahydrofolic acid which is an essential component. Synthetic ligands like methotrexate (MTX), aminopterin (AMP) and their analogues act as potential anti metabolites by mimicking the coenzyme d...

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Bibliographic Details
Main Authors:	Lingala Yamini, Manga Vijjulatha
Format:	Article
Language:	English
Published:	Hindawi Limited 2008-01-01
Series:	E-Journal of Chemistry
Online Access:	http://dx.doi.org/10.1155/2008/401738

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