Acquired Hemophilia A Presenting as Intramuscular Hematoma

Acquired Hemophilia A Presenting as Intramuscular Hematoma

Acquired hemophilia A poses a clinical and diagnostic challenge. Although rare, it is still the most common acquired factor deficiency. We present a case of acquired hemophilia A diagnosed in a 71-year-old female who presented with a right thigh hematoma of acute onset. The diagnosis was established...

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Main Authors: Ghassan Al-Shbool MD, Anusha Vakiti MD
Format: Article
Language:English
Published: SAGE Publishing 2018-12-01
Series:Journal of Investigative Medicine High Impact Case Reports
Online Access:https://doi.org/10.1177/2324709618817572
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spelling doaj-b9aec15561a541f4b48af0ebc9a434622020-11-25T03:08:35ZengSAGE PublishingJournal of Investigative Medicine High Impact Case Reports2324-70962018-12-01610.1177/2324709618817572Acquired Hemophilia A Presenting as Intramuscular HematomaGhassan Al-Shbool MD0Anusha Vakiti MD1MedStar Washington Hospital Center, Washington, DC, USAMedStar Washington Hospital Center, Washington, DC, USAAcquired hemophilia A poses a clinical and diagnostic challenge. Although rare, it is still the most common acquired factor deficiency. We present a case of acquired hemophilia A diagnosed in a 71-year-old female who presented with a right thigh hematoma of acute onset. The diagnosis was established based on the coagulation profile along with factor VIII levels, mixing studies, and inhibitor levels. The patient received multiple lines of therapy including steroids, factor VIIa, Obizur (porcine-derived recombinant factor VIII), followed by multiple cycles of chemotherapy including cyclophosphamide and rituximab.https://doi.org/10.1177/2324709618817572
collection DOAJ
language English
format Article
sources DOAJ
author Ghassan Al-Shbool MD
Anusha Vakiti MD
spellingShingle Ghassan Al-Shbool MD
Anusha Vakiti MD
Acquired Hemophilia A Presenting as Intramuscular Hematoma
Journal of Investigative Medicine High Impact Case Reports
author_facet Ghassan Al-Shbool MD
Anusha Vakiti MD
author_sort Ghassan Al-Shbool MD
title Acquired Hemophilia A Presenting as Intramuscular Hematoma
title_short Acquired Hemophilia A Presenting as Intramuscular Hematoma
title_full Acquired Hemophilia A Presenting as Intramuscular Hematoma
title_fullStr Acquired Hemophilia A Presenting as Intramuscular Hematoma
title_full_unstemmed Acquired Hemophilia A Presenting as Intramuscular Hematoma
title_sort acquired hemophilia a presenting as intramuscular hematoma
publisher SAGE Publishing
series Journal of Investigative Medicine High Impact Case Reports
issn 2324-7096
publishDate 2018-12-01
description Acquired hemophilia A poses a clinical and diagnostic challenge. Although rare, it is still the most common acquired factor deficiency. We present a case of acquired hemophilia A diagnosed in a 71-year-old female who presented with a right thigh hematoma of acute onset. The diagnosis was established based on the coagulation profile along with factor VIII levels, mixing studies, and inhibitor levels. The patient received multiple lines of therapy including steroids, factor VIIa, Obizur (porcine-derived recombinant factor VIII), followed by multiple cycles of chemotherapy including cyclophosphamide and rituximab.
url https://doi.org/10.1177/2324709618817572
work_keys_str_mv AT ghassanalshboolmd acquiredhemophiliaapresentingasintramuscularhematoma
AT anushavakitimd acquiredhemophiliaapresentingasintramuscularhematoma
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