Time-course gene expression data on the transcriptional effects of Aminaphtone on ECV304 endothelial cells

• Main Authors: Giulia Salazar, Chiara Bellocchi, Katia Todoerti, Federica Saporiti, Luca Piacentini, Raffaella Scorza, Gualtiero I. Colombo
• Format: Article
• Language: English
• Published: Elsevier 2016-09-01
• Series: Data in Brief
• Online Access: http://www.sciencedirect.com/science/article/pii/S235234091630419X

We previously showed that Aminaphtone, a drug used in the treatment of chronic venous insufficiency, modulates several vasoactive factors, such as endothelin-1 and adhesion molecules. Here, we provide data of time-course experiments about the effects of Aminaphtone on gene expression at the genome-wide level in human endothelial cells undergoing cytokine stimulation in vitro. ECV-304 endothelial cells were incubated with interleukin-1β (IL-1β) in the presence or absence of Aminaphtone for 1, 3, and 6 h. Gene expression profiles were analyzed by microarray. This article contains complete data on the genes significantly modulated by the drug over time. The data are supplemental to our original research article reporting detailed analysis of the actions of Aminaphtone on IL-1β stimulated endothelial cells at the molecular level, ''Gene expression profiling reveals novel protective effects of Aminaphtone on ECV304 endothelial cells'' (Salazar et al., 2016) [1]. Chemical compound studied in this article: Aminaphtone (PubChem CID: 84621), Keywords: Endothelial cells, Transcriptome, Inflammation, Vasoactive drug