Characterization and Identification of Poliovirus from the Environment in Indonesia 2015

• Main Authors: Bambang Heriyanto, Nike Susanti, Vivi Setiawaty
• Format: Article
• Language: English
• Published: DiscoverSys 2018-10-01
• Series: Bali Medical Journal
• Subjects: polio antibody, polio environment, circulation virus
• Online Access: https://balimedicaljournal.org/index.php/bmj/article/view/963
• ISSN: 2089-1180; 2302-2914

<p class="MsoNormal" style="text-align: justify;"><strong><span style="font-family: 'Times New Roman',serif;">Background</span></strong><span style="font-family: 'Times New Roman',serif;">: Poliomyelitis is a disease caused by the poliovirus which causes abnormalities in the nervous system, commonly affects children and can be prevented by immunization. Since March 27th, 2014, Indonesia has been declared to be free of polio and anticipate the mutation of poliovirus type 2 (vaccine-derived polioviruses / VDPV). Indonesia will change the use of policy vaccines from triOPV to biOPV by erasing the P2 type before switching from OPV to IPV. Before the policy was implemented, it is needed to have research to determine the level of immunity of children against poliovirus and type of poliovirus which circulate in the area of OPV and IPV in Indonesia. </span></p><p class="MsoNormal" style="text-align: justify;"><strong><span style="font-family: 'Times New Roman',serif;">Methods</span></strong><span style="font-family: 'Times New Roman',serif;">: The research study was conducted in five cities in five provinces in Indonesia in 2015. The serum was taken on 100 children between 12-59 months and feces were taken towards 150 children in the same age range. The examination of antibody titers in serum performed using the method of neutralization. </span></p><p class="MsoNormal" style="text-align: justify;"><strong><span style="font-family: 'Times New Roman',serif;">Result</span></strong><span style="font-family: 'Times New Roman',serif;">: Research shows that in regions that apply OPV as routine immunization, about 94.5% of children had antibodies against poliovirus type 1, 96.8% against type 2 and 93.3% of type 3. In areas which implement IPV as routine immunization, children have gained 85% immunity against poliovirus type 1, 92% against type 2 and 93% of type 3. In the environments that implement OPV, poliovirus was found in feces specimens (0.5%) or the mixed waste (58%). All the circulating virus is a virus originated from Sabin vaccine which mostly comes from type 2 (85% of mixed waste and 60% of feces). </span></p><p> </p><p class="MsoNormal" style="text-align: justify;"><strong><span style="font-family: 'Times New Roman',serif;">Conclusion</span></strong><span style="font-family: 'Times New Roman',serif;">: From this study, it can be concluded that sabin polio virus is still circulating in the area which applies OPV as routine immunization and poliovirus type 2 is commonly found there. Immunity inflicted on children varies in each region. Children living in a regular immunization using OPV and IPV had immunity for about 85-90%. </span></p><div><div><div id="_com_15" class="msocomtxt"><!--[if !supportAnnotations]--></div><!--[endif]--></div></div>