Stable carbon isotope discrimination by human 3-hydroxy-3-methylglutaryl-coenzyme A reductase

Stable carbon isotope discrimination by human 3-hydroxy-3-methylglutaryl-coenzyme A reductase

The aim of this study was to investigate the possible existence and magnitude of stable carbon isotope discrimination by human 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR). The catalytic portion of HMGR was expressed and purified. The reaction product mevalonate was lactonized and extracte...

Full description

Bibliographic Details
Main Authors: Svena M. Lüdke, Ulrich Flenker, Wilhelm Schänzer, Dietmar Schomburg
Format: Article
Language:English
Published: Elsevier 2008-12-01
Series:Journal of Lipid Research
Subjects:
mevalonate pathway
steroids
kinetic isotope effect
isotope ratio mass spectrometry
curve fitting
doping control
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520345922

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520345922

Similar Items