A transgenic minipig model of Huntington's disease shows early signs of behavioral and molecular pathologies

A transgenic minipig model of Huntington's disease shows early signs of behavioral and molecular pathologies

Huntington's disease (HD) is a monogenic, progressive, neurodegenerative disorder with currently no available treatment. The Libechov transgenic minipig model for HD (TgHD) displays neuroanatomical similarities to humans and exhibits slow disease progression, and is therefore more powerful than...

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Bibliographic Details
Main Authors: Georgina Askeland, Marie Rodinova, Hana Štufková, Zaneta Dosoudilova, Monika Baxa, Petra Smatlikova, Bozena Bohuslavova, Jiri Klempir, The Duong Nguyen, Anna Kuśnierczyk, Magnar Bjørås, Arne Klungland, Hana Hansikova, Zdenka Ellederova, Lars Eide
Format: Article
Language:English
Published: The Company of Biologists 2018-10-01
Series:Disease Models & Mechanisms
Subjects:
Huntington's disease
Mitochondrial function
DNA damage
DNA repair
HD large animal model
Online Access:http://dmm.biologists.org/content/11/10/dmm035949

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