Biomembrane mimics and their roles in anti-bacterial drug discovery

Biomembrane mimics and their roles in anti-bacterial drug discovery

Cell membrane is at the frontline of the battle between pathogenic microbe and host. A thorough understanding of bacterial membrane is fundamental to tackle infection disease. Membrane mimetic provides a powerful tool for mechanistic interrogation of drug-membrane interaction. Herein, we summarized...

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Bibliographic Details
Main Authors: Xiaohui Hu, Kin Tam
Format: Article
Language:English
Published: International Association of Physical Chemists (IAPC) 2017-03-01
Series:ADMET and DMPK
Subjects:
Drug-membrane interaction
mode of action
liposome
supported lipid bilayer
resistance
Online Access:http://pub.iapchem.org/ojs/index.php/admet/article/view/375
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spelling doaj-b9a80c95c4eb4ec49b7f8df1412385a22020-11-25T01:05:12ZengInternational Association of Physical Chemists (IAPC)ADMET and DMPK1848-77182017-03-015191310.5599/admet.5.1.375243Biomembrane mimics and their roles in anti-bacterial drug discoveryXiaohui HuKin TamCell membrane is at the frontline of the battle between pathogenic microbe and host. A thorough understanding of bacterial membrane is fundamental to tackle infection disease. Membrane mimetic provides a powerful tool for mechanistic interrogation of drug-membrane interaction. Herein, we summarized major features of bacterial and mammalian cell in context of antibacterial therapy. Much details were given to model membranes and their application in mechanistic studies. Current challenge in antibacterial therapy and perspective of membrane mimics in antibacterial drug discovery were also provided.http://pub.iapchem.org/ojs/index.php/admet/article/view/375Drug-membrane interactionmode of actionliposomesupported lipid bilayerresistance
collection DOAJ
language English
format Article
sources DOAJ
author Xiaohui Hu
Kin Tam
spellingShingle Xiaohui Hu
Kin Tam
Biomembrane mimics and their roles in anti-bacterial drug discovery
ADMET and DMPK
Drug-membrane interaction
mode of action
liposome
supported lipid bilayer
resistance
author_facet Xiaohui Hu
Kin Tam
author_sort Xiaohui Hu
title Biomembrane mimics and their roles in anti-bacterial drug discovery
title_short Biomembrane mimics and their roles in anti-bacterial drug discovery
title_full Biomembrane mimics and their roles in anti-bacterial drug discovery
title_fullStr Biomembrane mimics and their roles in anti-bacterial drug discovery
title_full_unstemmed Biomembrane mimics and their roles in anti-bacterial drug discovery
title_sort biomembrane mimics and their roles in anti-bacterial drug discovery
publisher International Association of Physical Chemists (IAPC)
series ADMET and DMPK
issn 1848-7718
publishDate 2017-03-01
description Cell membrane is at the frontline of the battle between pathogenic microbe and host. A thorough understanding of bacterial membrane is fundamental to tackle infection disease. Membrane mimetic provides a powerful tool for mechanistic interrogation of drug-membrane interaction. Herein, we summarized major features of bacterial and mammalian cell in context of antibacterial therapy. Much details were given to model membranes and their application in mechanistic studies. Current challenge in antibacterial therapy and perspective of membrane mimics in antibacterial drug discovery were also provided.
topic Drug-membrane interaction
mode of action
liposome
supported lipid bilayer
resistance
url http://pub.iapchem.org/ojs/index.php/admet/article/view/375
work_keys_str_mv AT xiaohuihu biomembranemimicsandtheirrolesinantibacterialdrugdiscovery
AT kintam biomembranemimicsandtheirrolesinantibacterialdrugdiscovery
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