Transient muscarinic and glutamatergic stimulation of neural stem cells triggers acute and persistent changes in differentiation

Transient muscarinic and glutamatergic stimulation of neural stem cells triggers acute and persistent changes in differentiation

While aberrant cell proliferation and differentiation may contribute to epileptogenesis, the mechanisms linking an initial epileptic insult to subsequent changes in cell fate remain elusive. Using both mouse and human iPSC-derived neural progenitor/stem cells (NPSCs), we found that a combined transi...

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Bibliographic Details
Main Authors: Ranmal A. Samarasinghe, Prasad S. Kanuparthi, J. Timothy Greenamyre, Donald B. DeFranco, Roberto Di Maio
Format: Article
Language:English
Published: Elsevier 2014-10-01
Series:Neurobiology of Disease
Subjects:
Connexin
Neural stem cell
Glutamate receptor
Epileptogenesis
Pilocarpine
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114001843

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