Increased Regeneration Following Stress-Induced Lung Injury in Bleomycin-Treated Chimeric Mice with CD44 Knockout Mesenchymal Cells

Increased Regeneration Following Stress-Induced Lung Injury in Bleomycin-Treated Chimeric Mice with CD44 Knockout Mesenchymal Cells

CD44, an adhesion-molecule promoting cell-migration, is shown here to increase in stress conditions following bleomycin-induced apoptosis in alveolar epithelial cells (AECs), a main target of lung injury. In vivo, it inhibits tissue regeneration and leads to fibrosis. We show that some AECs survive...

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Bibliographic Details
Main Authors: Dmytro Petukhov, Mark Richter-Dayan, Zvi Fridlender, Raphael Breuer, Shulamit B. Wallach-Dayan
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Cells
Subjects:
regeneration
fibrosis
oxidative stress
bleomycin
cell-survival
epithelial-mesenchymal transition
atm
cd44
Online Access:https://www.mdpi.com/2073-4409/8/10/1211

Internet

https://www.mdpi.com/2073-4409/8/10/1211

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