Advances in ER-Phagy and Its Diseases Relevance

As an important form of selective autophagy in cells, ER-phagy (endoplasmic reticulum-selective autophagy), the autophagic degradation of endoplasmic reticulum (ER), degrades ER membranes and proteins to maintain cellular homeostasis. The relationship between ER-phagy and human diseases, including n...

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Main Authors:	Lingang He, Xuehong Qian, Yixian Cui
Format:	Article
Language:	English
Published:	MDPI AG 2021-09-01
Series:	Cells
Subjects:	ER-phagy receptor neurodegenerative diseases cancer metabolic diseases
Online Access:	https://www.mdpi.com/2073-4409/10/9/2328

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spelling	doaj-b99d09b1b1254a9680aee5e84c13ded72021-09-25T23:52:36ZengMDPI AGCells2073-44092021-09-01102328232810.3390/cells10092328Advances in ER-Phagy and Its Diseases RelevanceLingang He0Xuehong Qian1Yixian Cui2Department of Neurosurgery, Zhongnan Hospital, Wuhan University, Wuhan 430071, ChinaDepartment of Neurosurgery, Zhongnan Hospital, Wuhan University, Wuhan 430071, ChinaDepartment of Neurosurgery, Zhongnan Hospital, Wuhan University, Wuhan 430071, ChinaAs an important form of selective autophagy in cells, ER-phagy (endoplasmic reticulum-selective autophagy), the autophagic degradation of endoplasmic reticulum (ER), degrades ER membranes and proteins to maintain cellular homeostasis. The relationship between ER-phagy and human diseases, including neurodegenerative disorders, cancer, and other metabolic diseases has been unveiled by extensive research in recent years. Starting with the catabolic process of ER-phagy and key mediators in this pathway, this paper reviews the advances in the mechanism of ER-phagy and its diseases relevance. We hope to provide some enlightenment for further study on ER-phagy and the development of novel therapeutic strategies for related diseases.https://www.mdpi.com/2073-4409/10/9/2328ER-phagyreceptorneurodegenerative diseasescancermetabolic diseases
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Lingang He Xuehong Qian Yixian Cui
spellingShingle	Lingang He Xuehong Qian Yixian Cui Advances in ER-Phagy and Its Diseases Relevance Cells ER-phagy receptor neurodegenerative diseases cancer metabolic diseases
author_facet	Lingang He Xuehong Qian Yixian Cui
author_sort	Lingang He
title	Advances in ER-Phagy and Its Diseases Relevance
title_short	Advances in ER-Phagy and Its Diseases Relevance
title_full	Advances in ER-Phagy and Its Diseases Relevance
title_fullStr	Advances in ER-Phagy and Its Diseases Relevance
title_full_unstemmed	Advances in ER-Phagy and Its Diseases Relevance
title_sort	advances in er-phagy and its diseases relevance
publisher	MDPI AG
series	Cells
issn	2073-4409
publishDate	2021-09-01
description	As an important form of selective autophagy in cells, ER-phagy (endoplasmic reticulum-selective autophagy), the autophagic degradation of endoplasmic reticulum (ER), degrades ER membranes and proteins to maintain cellular homeostasis. The relationship between ER-phagy and human diseases, including neurodegenerative disorders, cancer, and other metabolic diseases has been unveiled by extensive research in recent years. Starting with the catabolic process of ER-phagy and key mediators in this pathway, this paper reviews the advances in the mechanism of ER-phagy and its diseases relevance. We hope to provide some enlightenment for further study on ER-phagy and the development of novel therapeutic strategies for related diseases.
topic	ER-phagy receptor neurodegenerative diseases cancer metabolic diseases
url	https://www.mdpi.com/2073-4409/10/9/2328
work_keys_str_mv	AT linganghe advancesinerphagyanditsdiseasesrelevance AT xuehongqian advancesinerphagyanditsdiseasesrelevance AT yixiancui advancesinerphagyanditsdiseasesrelevance
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Advances in ER-Phagy and Its Diseases Relevance

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