Comparison of iguratimod and conventional cyclophosphamide with sequential azathioprine as treatment of active lupus nephritis: study protocol for a multi-center, randomized, controlled clinical trial (iGeLU study)

Comparison of iguratimod and conventional cyclophosphamide with sequential azathioprine as treatment of active lupus nephritis: study protocol for a multi-center, randomized, controlled clinical trial (iGeLU study)

Abstract Background Systemic lupus erythematosus (SLE) is an autoimmune disease that can involve multiple organs or systems. Lupus nephritis (LN) is associated with high mortality and morbidity. However, plenty of patients do not respond to present treatment or relapse. Iguratimod (IGU) is a new sma...

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Main Authors: Qingran Yan, Fang Du, Yuening Kang, Ping Ye, Xiaodong Wang, Jianhua Xu, Jianping Tang, Niansong Wang, Gengru Jiang, Zhijun Li, Xuan Wang, Qin Xue, Xinfang Huang, Xiaoyan Zhang, Ying Zhou, Min Dai, Chunde Bao
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Trials
Subjects:
Systemic lupus erythematosus
Active lupus nephritis
Randomized clinical trial
Iguratimod
Cyclophosphamide
treatment
Online Access:https://doi.org/10.1186/s13063-021-05475-3

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