Increased Potency of a Bi-specific TL1A-ADAM17 (TACE) Inhibitor by Cell Surface Targeting

Increased Potency of a Bi-specific TL1A-ADAM17 (TACE) Inhibitor by Cell Surface Targeting

Inflammatory bowel disease (IBD) is a multifactorial disease characterized by the dysregulated activity of many pro-inflammatory factors. Thus, bi-specific inhibitors for the simultaneous inhibition of two pro-inflammatory factors can exhibit high therapeutic potential. Here, we developed a novel bi...

Full description

Bibliographic Details
Main Authors: Tomer Weizman, Itay Levin, Marianna Zaretsky, Irit Sagi, Amir Aharoni
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Molecular Biosciences
Subjects:
bi-specific inhibitors
protein engineering
pro-inflammatory cytokines
metalloproteases
TL1A
TACE
Online Access:http://journal.frontiersin.org/article/10.3389/fmolb.2017.00061/full

Internet

http://journal.frontiersin.org/article/10.3389/fmolb.2017.00061/full

Similar Items