ALZHEIMER’S DISEASE: DIAGNOSIS AND TREATMENT

• Main Authors: A. A. Naumenko, D. O. Gromova, N. V. Trofimova, I. S. Preobrazhenskaya
• Format: Article
• Language: Russian
• Published: IMA-PRESS LLC 2016-12-01
• Series: Nevrologiâ, Nejropsihiatriâ, Psihosomatika
• Subjects: alzheimer disease; cerebral amyloidosis; basic symptomatic treatment; central acetylcholinesterase inhibitors; nmda receptor blockers; akatinol memantine; gantenerumab; nootropic therapy; cerebrolysin; non-drug exposures; cognitive-motor training
• Online Access: https://nnp.ima-press.net/nnp/article/view/680
• ISSN: 2074-2711; 2310-1342

Early diagnosis of Alzheimer's disease (AD) is one of the most important tasks of modern medicine. Even before its obvious clinical symptoms develop, AD can be now identified from the data of functional neuroimaging, including that with the Pittsburgh compound, which can detect amyloid protein accumulation in the brain structures, and from those of an analysis of biomarkers in the cerebrospinal fluid. If there are clinical symptoms, a diagnosis can be established by the correct evaluation of mnestic disorders; the latter in BA are so-called hippocampal. Treatment for AD should be initiated as early as possible; methods for pathogenetic therapy are being actively developed. When treating AD, one should adhere to a comprehensive approach involving the use of drugs for basic symptomatic treatment and those enhancing its efficiency, and non-drug treatments (cognitive and motor training). It is important to timely identify and eliminate potentially reversible conditions and to work with caregivers and guardians.