Microhomology directs diverse DNA break repair pathways and chromosomal translocations.

Microhomology directs diverse DNA break repair pathways and chromosomal translocations.

Chromosomal structural change triggers carcinogenesis and the formation of other genetic diseases. The breakpoint junctions of these rearrangements often contain small overlapping sequences called "microhomology," yet the genetic pathway(s) responsible have yet to be defined. We report a s...

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Bibliographic Details
Main Authors: Diana D Villarreal, Kihoon Lee, Angela Deem, Eun Yong Shim, Anna Malkova, Sang Eun Lee
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3493447?pdf=render

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