Pro-Resolving Mediator Annexin A1 Regulates Intracellular Ca2+ and Mucin Secretion in Cultured Goblet Cells Suggesting a New Use in Inflammatory Conjunctival Diseases

Pro-Resolving Mediator Annexin A1 Regulates Intracellular Ca2+ and Mucin Secretion in Cultured Goblet Cells Suggesting a New Use in Inflammatory Conjunctival Diseases

The amount of mucin secreted by conjunctival goblet cells is regulated to ensure the optimal level for protection of the ocular surface. Under physiological conditions lipid specialized pro-resolving mediators (SPM) are essential for maintaining tissue homeostasis including the conjunctiva. The prot...

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Bibliographic Details
Main Authors: Anne V. Lyngstadaas, Markus V. Olsen, Jeffrey A. Bair, Robin R. Hodges, Tor P. Utheim, Charles N. Serhan, Darlene A. Dartt
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
ocular surface
annexin A1
secretion
specialized pro resolving mediators
mucin
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.618653/full

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