INFLUENCE OF ANTHELMINTIC DRUGS ON ACTIVITIES OF 5'-NUCLEOTIDASE Bothriocephalus scorpii (Cestoda: Bothriocephalidae)
Activities and properties of 5'-nucleotidase in the subcellular fractions of Bothriocephalus scorpii are studied with the use of adenosine monophosphate, inosine monophosphate and cytidine monophosphate as substrates. The high activity of 5'-nucleotidase was observed in the mitochondrial f...
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| Format: | Article |
| Language: | Russian |
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Federal Scientific Centre VIEV
2016-05-01
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| Series: | Российский паразитологический журнал |
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| Online Access: | https://vniigis.elpub.ru/jour/article/view/284 |
| Summary: | Activities and properties of 5'-nucleotidase in the subcellular fractions of Bothriocephalus scorpii are studied with the use of adenosine monophosphate, inosine monophosphate and cytidine monophosphate as substrates. The high activity of 5'-nucleotidase was observed in the mitochondrial fraction. Dependence of the 5'-nucleotidase activity on the concentration of substrates and Mn2+ ions is investigated. Impact of various effectors and ions (sodium fluoride, EDTA, cysteine, K+, Na+ , Zn2+, Ca2+, Ba2+, Cu2+, Mn2+) on enzyme activity is determined. Effect of 10 anthelmintic drugs on enzyme activity has been tested. The most effective drugs are bitionol and oxinide. |
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| ISSN: | 1998-8435 2541-7843 |