Identification of novel small molecule inhibitors for solute carrier SGLT1 using proteochemometric modeling

Identification of novel small molecule inhibitors for solute carrier SGLT1 using proteochemometric modeling

Abstract Sodium-dependent glucose co-transporter 1 (SGLT1) is a solute carrier responsible for active glucose absorption. SGLT1 is present in both the renal tubules and small intestine. In contrast, the closely related sodium-dependent glucose co-transporter 2 (SGLT2), a protein that is targeted in...

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Bibliographic Details
Main Authors: Lindsey Burggraaff, Paul Oranje, Robin Gouka, Pieter van der Pijl, Marian Geldof, Herman W. T. van Vlijmen, Adriaan P. IJzerman, Gerard J. P. van Westen
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Journal of Cheminformatics
Subjects:
Sodium-dependent glucose co-transporter
Sodium-glucose linked transporter
SGLT1
Proteochemometrics
Molecular modeling
Machine learning
Online Access:http://link.springer.com/article/10.1186/s13321-019-0337-8

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