Pure total flavonoids from citrus attenuate non-alcoholic steatohepatitis via regulating the gut microbiota and bile acid metabolism in mice

Pure total flavonoids from citrus attenuate non-alcoholic steatohepatitis via regulating the gut microbiota and bile acid metabolism in mice

Background: Our previous studies found that Pure total flavnoids from citrus (PTFC) can effectively improve non-alcoholic steatohepatitis (NASH) in mice. Here, we discuss on the mechanism of PTFC in treating NASH with focus on the regulation of the gut microbiota and bile acid metabolism. Methods: C...

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Bibliographic Details
Main Authors: Beihui He, Jianping Jiang, Zheng Shi, Liyan Wu, Junbin Yan, Zheng Chen, Minmin Luo, Dawei Cui, Sumei Xu, Maoxiang Yan, Shuo Zhang, Zhiyun Chen
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Pure total flavonoids from citrus
Non-alcoholic steatohepatitis
Gut microbiota
Bile acid
FXR
TGR5
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220313767

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