Bone corticalization requires local SOCS3 activity and is promoted by androgen action via interleukin-6
The strength of long bones is determined by coalescence of trabeculae during corticalization. Here the authors show that this process is regulated by SOCS3 via a mechanism dependent on IL-6 and expression of sex hormones.
Bibliographic Details
| Main Authors: |
Dae-Chul Cho,
Holly J. Brennan,
Rachelle W. Johnson,
Ingrid J. Poulton,
Jonathan H. Gooi,
Brett A. Tonkin,
Narelle E. McGregor,
Emma C. Walker,
David J. Handelsman,
T. J. Martin,
Natalie A. Sims |
|---|
| Format: | Article
|
|---|
| Language: | English |
|---|
| Published: |
Nature Publishing Group
2017-10-01
|
|---|
| Series: | Nature Communications
|
|---|
| Online Access: | https://doi.org/10.1038/s41467-017-00920-x
|
|---|
