Modeling appendicular skeletal cartilage development with modified high-density micromass cultures of adult human bone marrow-derived mesenchymal progenitor cells

Abstract Background Animal cell-based systems have been critical tools in understanding tissue development and physiology, but they are less successful in more practical tasks, such as predicting human toxicity to pharmacological or environmental factors, in which the congruence between in vitro and...

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Bibliographic Details
Main Authors: Alessandro Pirosa, Karen L. Clark, Jian Tan, Shuting Yu, Yuanheng Yang, Rocky S. Tuan, Peter G. Alexander
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Stem Cell Research & Therapy
Subjects:
Online Access:https://doi.org/10.1186/s13287-019-1505-5