The Dual Role of Kinin/Kinin Receptors System in Alzheimer’s Disease

• Main Authors: Bingyuan Ji, Qinqin Wang, Qingjie Xue, Wenfu Li, Xuezhi Li, Yili Wu
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2019-10-01
• Series: Frontiers in Molecular Neuroscience
• Subjects: Alzheimer’s disease; kinins receptors; amyloid beta; neuroinflammation; neuroprotection
• Online Access: https://www.frontiersin.org/article/10.3389/fnmol.2019.00234/full
• ISSN: 1662-5099

Alzheimer’s disease (AD) is the most common neurodegenerative disease characterized by progressive spatial disorientation, learning and memory deficits, responsible for 60%–80% of all dementias. However, the pathological mechanism of AD remains unknown. Numerous studies revealed that kinin/kinin receptors system (KKS) may be involved in the pathophysiology of AD. In this review article, we summarized the roles of KKS in neuroinflammation, cerebrovascular impairment, tau phosphorylation, and amyloid β (Aβ) generation in AD. Moreover, we provide new insights into the mechanistic link between KKS and AD, and highlight the KKS as a potential therapeutic target for AD treatment.