Olfactomedin-1 activity identifies a cell invasion checkpoint during epithelial-mesenchymal transition in the chick embryonic heart

Olfactomedin-1 activity identifies a cell invasion checkpoint during epithelial-mesenchymal transition in the chick embryonic heart

SUMMARY Endothelia in the atrioventricular (AV) canal of the developing heart undergo a prototypical epithelial mesenchymal transition (EMT) to begin heart valve formation. Using an in vitro invasion assay, an extracellular matrix protein, Olfactomedin-1 (OLFM1), was found to increase mesenchymal ce...

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Bibliographic Details
Main Authors: Alejandro Lencinas, Danny C. Chhun, Kelvin P. Dan, Kristen D. Ross, Elizabeth A. Hoover, Parker B. Antin, Raymond B. Runyan
Format: Article
Language:English
Published: The Company of Biologists 2013-05-01
Series:Disease Models & Mechanisms
Online Access:http://dmm.biologists.org/content/6/3/632

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http://dmm.biologists.org/content/6/3/632

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