Deciphering the Nature of <i>Trp</i>73 Isoforms in Mouse Embryonic Stem Cell Models: Generation of Isoform-Specific Deficient Cell Lines Using the CRISPR/Cas9 Gene Editing System

Deciphering the Nature of <i>Trp</i>73 Isoforms in Mouse Embryonic Stem Cell Models: Generation of Isoform-Specific Deficient Cell Lines Using the CRISPR/Cas9 Gene Editing System

The p53 family has been widely studied for its role in various physiological and pathological processes. Imbalance of p53 family proteins may contribute to developmental abnormalities and pathologies in humans. This family exerts its functions through a profusion of isoforms that are generated by di...

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Bibliographic Details
Main Authors: Lorena López-Ferreras, Nicole Martínez-García, Laura Maeso-Alonso, Marta Martín-López, Ángela Díez-Matilla, Javier Villoch-Fernandez, Hugo Alonso-Olivares, Margarita M. Marques, Maria C. Marin
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cancers
Subjects:
p73 isoforms
TAp73
DNp73
mouse embryonic stem cells (mESC)
gene editing
pluripotency
Online Access:https://www.mdpi.com/2072-6694/13/13/3182

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