GT-Repeat Polymorphism in the HO-1 Gene Promoter Is Associated with Risk of Liver Cancer: A Follow-Up Study from Arseniasis-Endemic Areas in Taiwan

GT-Repeat Polymorphism in the HO-1 Gene Promoter Is Associated with Risk of Liver Cancer: A Follow-Up Study from Arseniasis-Endemic Areas in Taiwan

The induction of heme oxygenase-1 (HO-1) has been shown to have therapeutic potential in experimental models of hepatitis and liver fibrosis, which are closely related to liver cancer. In humans, HO-1 induction is transcriptionally modulated by the length of a GT-repeat [(GT)n] in the promoter regio...

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Bibliographic Details
Main Authors: Meei-Maan Wu, Fang-I Hsieh, Ling-I Hsu, Te-Chang Lee, Hung-Yi Chiou, Chien-Jen Chen
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Journal of Clinical Medicine
Subjects:
heme oxygenase-1
genetic polymorphism
liver cancer
cirrhosis
arsenic
epidemiology
Online Access:https://www.mdpi.com/2077-0383/10/7/1489

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