Molecular docking studies of salubrinal and its analogs as inhibitors of the GADD34:PP1 enzyme

Molecular docking studies of salubrinal and its analogs as inhibitors of the GADD34:PP1 enzyme

The phenomenon of the endoplasmic reticulum (ER) stress as a molecular pathophysiological process underlies diseases as cancer, diabetes mellitus, myocardial infarction, neurodegenerative disorders, diseases of the urinary system, disorders associated with bone integrity, etc. To prevent ER stress,...

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Bibliographic Details
Main Authors: Pavlo V. Zadorozhnii, Ihor O. Pokotylo, Vadym V. Kiselev, Oxana V. Okhtina, Aleksandr V. Kharchenko
Format: Article
Language:English
Published: International Association of Physical Chemists (IAPC) 2019-04-01
Series:ADMET and DMPK
Subjects:
Salubrinal
molecular docking
GADD34:PP1
RMSD
endoplasmic reticulum stress
Online Access:http://pub.iapchem.org/ojs/index.php/admet/article/view/632

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http://pub.iapchem.org/ojs/index.php/admet/article/view/632

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