Role of Autophagy as a Survival Mechanism for Hypoxic Cells in Tumors

Role of Autophagy as a Survival Mechanism for Hypoxic Cells in Tumors

Enhanced autophagy has been observed in hypoxic regions of solid tumors. Here we address the hypothesis that autophagy is required for survival of hypoxic cells. We evaluated sensitivity to hypoxia of three human tumor cell lines (MCF7, PC3, and LNCaP) and their autophagy-deficient variants with shR...

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Bibliographic Details
Main Authors:	Qian Tan, Marina Wang, Man Yu, Junyan Zhang, Robert G Bristow, Richard P Hill, Ian F Tannock
Format:	Article
Language:	English
Published:	Elsevier 2016-06-01
Series:	Neoplasia: An International Journal for Oncology Research
Online Access:	http://www.sciencedirect.com/science/article/pii/S1476558616300161

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