Relationship between composition and organizational levels of nanostructured systems formed by Oleth 10 and PPG-5-Ceteth-20 for potential drug delivery

• Main Authors: Nathalia Cristina Rissi, Danila Aparecida Scatolin Guglielmi, Marcos Antônio Corrêa, Leila Aparecida Chiavacci
• Format: Article
• Language: English
• Published: Universidade de São Paulo 2014-09-01
• Series: Brazilian Journal of Pharmaceutical Sciences
• Subjects: Diagramas de fases ternários; Sistemas nanoestruturados; Curvas de dispersão de raios X de pequeno ângulo/perfis; Fármacos/sistems de liberação
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000300653&lng=en&tlng=en

In this paper, nanostructured systems were developed, with the aid of ternary phase diagrams, from two surfactants, of differing degrees of lipophilicity (PPG-5-Ceteth-20 and the Oleth 10) and two oil phases (oleic acid and isopropyl myristate). It was observed that there were differences between the four resulting phase diagrams in the physical properties of the systems they represent. Thus, due to the capacity of Oleth 10 (as surfactant) and oleic acid (as the oil phase) to reduce interfacial tension, large regions of translucent systems were seen on the diagrams produced by them. By polarized light microscopy, it was possible to identify the isotropic and anisotropic properties of these systems, which were confirmed by small-angle X-ray scattering (SAXS) analysis. Furthermore, it was found that increasing the proportion of water in the formulations led to more highly organized structures, resulting in narrower and well defined SAXS peaks.