HDAC1 Silence Promotes Neuroprotective Effects of Human Umbilical Cord-Derived Mesenchymal Stem Cells in a Mouse Model of Traumatic Brain Injury via PI3K/AKT Pathway

HDAC1 Silence Promotes Neuroprotective Effects of Human Umbilical Cord-Derived Mesenchymal Stem Cells in a Mouse Model of Traumatic Brain Injury via PI3K/AKT Pathway

Stem cell transplantation is a promising therapy for traumatic brain injury (TBI), but low efficiency of survival and differentiation of transplanted stem cells limits its clinical application. Histone deacetylase 1 (HDAC1) plays important roles in self-renewal of stem cells as well as the recovery...

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Bibliographic Details
Main Authors: Ling Xu, Qu Xing, Tuanjie Huang, Jiankang Zhou, Tengfei Liu, Yuanbo Cui, Tian Cheng, Yaping Wang, Xinkui Zhou, Bo Yang, Greta Luyuan Yang, Jiewen Zhang, Xingxing Zang, Shanshan Ma, Fangxia Guan
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Cellular Neuroscience
Subjects:
histone deacetylase 1
human umbilical cord derived mesenchymal stem cells
traumatic brain injury
neuroprotection
PI3K/AKT
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00498/full

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