| Summary: | Purpose: This study was to analyze
the efficacy and safety of thulium laser
resection of bladder tumor (Tm-TURBT) versus TURBT for patients with
non-muscle-invasive bladder cancer (NMIBC). Materials and Methods: Randomized controlled trial data were
retrieved using the MEDLINE, Embase, Web of
Science, and the Cochrane Library. We also searched Chinese databases
including
Chinese National Knowledge Infrastructure
(CNKI), Wanfang data and VIP data. Results: A total of sixteen articles including 1662 participants were enrolled into our
meta-analysis. We found no significant difference in terms of operation time,
urethral stricture, 1-year recurrence rate, overall 1-year recurrence rate and
overall 3-year recurrence rate between the two groups. Less intraoperative blood
loss and a lower incidence of
obturator
nerve reflex (ONR), bladder perforation and bladder irritation were identified in
Tm-TURBT group than in TURBT group in our analysis. The analysis also
demonstrated faster postoperative recovery in terms of the catheterization,
bladder irrigation and hospitalization time in Tm-TURBT group. The subgroup
analysis was conducted based on different postoperative chemotherapy (epirubicin
and non-epirubicin) concerning recurrence rate whereas no significant difference
was noted. Conclusion: Tm-TURBT is an
efficient and safe treatment for NMIBC and it could be an alternative choice for
TURBT. Given that some limitations are clearly identified, more large-scale and
well-designed RCTs are needed to confirm our findings.
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