The Significance of Long Noncoding RNA H19 in Predicting Progression and Metastasis of Cancers: A Meta-Analysis
Recently, numerous studies indicate that H19 plays a key role in tumorigenesis, but the results have been disputed, especially in the aspects of tumor progression and metastasis. Therefore, we performed this meta-analysis to systematically summarize the relationship between H19 and cancers. We searc...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2016-01-01
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| Series: | BioMed Research International |
| Online Access: | http://dx.doi.org/10.1155/2016/5902678 |
| Summary: | Recently, numerous studies indicate that H19 plays a key role in tumorigenesis, but the results have been disputed, especially in the aspects of tumor progression and metastasis. Therefore, we performed this meta-analysis to systematically summarize the relationship between H19 and cancers. We searched PubMed, the Cochrane Library, CNKI, and Chinese Wan Fang to identify eligible studies. Odds ratios and 95% confidence intervals were calculated to assess the effect size. A total of 13 studies were enrolled in this meta-analysis, which was performed by Revman5.3 and Stata11.0 software. Our meta-analysis showed that the expression of H19 was associated with distant metastasis in nongastrointestinal tumors (OR = 3.85, 95% CI = 1.31–11.36, P=0.01) and, in gastrointestinal tumors (OR = 0.34, 95% CI = 0.15–0.78, P=0.01), lymph node metastasis (OR = 2.04, 95% CI = 1.19–3.48, P=0.009). Moreover, in gastric cancer, H19 expression was significantly related to histological grade (OR = 0.50, 95% CI = 0.29–0.86, P=0.01), TNM stage (OR = 0.19, 95% CI = 0.11–0.33, P<0.01), and tumor invasion depth (OR = 0.11, 95% CI = 0.04–0.27, P<0.01). Therefore, H19 could serve as a potential marker for progression and metastasis evaluation of cancers. |
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| ISSN: | 2314-6133 2314-6141 |