Germline and somatic genetic alterations in two first‐degree relatives with appendiceal low‐grade mucinous carcinoma peritonei

Germline and somatic genetic alterations in two first‐degree relatives with appendiceal low‐grade mucinous carcinoma peritonei

Abstract Comparing genetic mutations of first‐degree relatives with appendiceal pseudomyxoma peritonei may explain clinical outcomes and disease pathogenesis. Molecular profiling of mucinous tumors may identify improved treatments to traditional chemotherapy.

Bibliographic Details
Main Authors: Mary Caitlin King, Carlos Munoz‐Zuluaga, Panayotis Ledakis, Kimberley Studeman, Michelle Sittig, Vadim Gushchin, Armando Sardi
Format: Article
Language:English
Published: Wiley 2020-12-01
Series:Clinical Case Reports
Subjects:
appendix cancer
genetic analysis
hyperthermic intraperitoneal chemotherapy
next‐generation sequencing
pseudomyxoma peritonei
Online Access:https://doi.org/10.1002/ccr3.3338
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spelling doaj-b8f6328d5c764ed2b1af654e60d1d7e42021-08-02T06:23:38ZengWileyClinical Case Reports2050-09042020-12-018123167317610.1002/ccr3.3338Germline and somatic genetic alterations in two first‐degree relatives with appendiceal low‐grade mucinous carcinoma peritoneiMary Caitlin King0Carlos Munoz‐Zuluaga1Panayotis Ledakis2Kimberley Studeman3Michelle Sittig4Vadim Gushchin5Armando Sardi6The Institute for Cancer Care Mercy Medical Center Baltimore MD USAThe Institute for Cancer Care Mercy Medical Center Baltimore MD USAThe Institute for Cancer Care Mercy Medical Center Baltimore MD USADepartment of Pathology Mercy Medical Center Baltimore MD USAThe Institute for Cancer Care Mercy Medical Center Baltimore MD USAThe Institute for Cancer Care Mercy Medical Center Baltimore MD USAThe Institute for Cancer Care Mercy Medical Center Baltimore MD USAAbstract Comparing genetic mutations of first‐degree relatives with appendiceal pseudomyxoma peritonei may explain clinical outcomes and disease pathogenesis. Molecular profiling of mucinous tumors may identify improved treatments to traditional chemotherapy.https://doi.org/10.1002/ccr3.3338appendix cancergenetic analysishyperthermic intraperitoneal chemotherapynext‐generation sequencingpseudomyxoma peritonei
collection DOAJ
language English
format Article
sources DOAJ
author Mary Caitlin King
Carlos Munoz‐Zuluaga
Panayotis Ledakis
Kimberley Studeman
Michelle Sittig
Vadim Gushchin
Armando Sardi
spellingShingle Mary Caitlin King
Carlos Munoz‐Zuluaga
Panayotis Ledakis
Kimberley Studeman
Michelle Sittig
Vadim Gushchin
Armando Sardi
Germline and somatic genetic alterations in two first‐degree relatives with appendiceal low‐grade mucinous carcinoma peritonei
Clinical Case Reports
appendix cancer
genetic analysis
hyperthermic intraperitoneal chemotherapy
next‐generation sequencing
pseudomyxoma peritonei
author_facet Mary Caitlin King
Carlos Munoz‐Zuluaga
Panayotis Ledakis
Kimberley Studeman
Michelle Sittig
Vadim Gushchin
Armando Sardi
author_sort Mary Caitlin King
title Germline and somatic genetic alterations in two first‐degree relatives with appendiceal low‐grade mucinous carcinoma peritonei
title_short Germline and somatic genetic alterations in two first‐degree relatives with appendiceal low‐grade mucinous carcinoma peritonei
title_full Germline and somatic genetic alterations in two first‐degree relatives with appendiceal low‐grade mucinous carcinoma peritonei
title_fullStr Germline and somatic genetic alterations in two first‐degree relatives with appendiceal low‐grade mucinous carcinoma peritonei
title_full_unstemmed Germline and somatic genetic alterations in two first‐degree relatives with appendiceal low‐grade mucinous carcinoma peritonei
title_sort germline and somatic genetic alterations in two first‐degree relatives with appendiceal low‐grade mucinous carcinoma peritonei
publisher Wiley
series Clinical Case Reports
issn 2050-0904
publishDate 2020-12-01
description Abstract Comparing genetic mutations of first‐degree relatives with appendiceal pseudomyxoma peritonei may explain clinical outcomes and disease pathogenesis. Molecular profiling of mucinous tumors may identify improved treatments to traditional chemotherapy.
topic appendix cancer
genetic analysis
hyperthermic intraperitoneal chemotherapy
next‐generation sequencing
pseudomyxoma peritonei
url https://doi.org/10.1002/ccr3.3338
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AT carlosmunozzuluaga germlineandsomaticgeneticalterationsintwofirstdegreerelativeswithappendiceallowgrademucinouscarcinomaperitonei
AT panayotisledakis germlineandsomaticgeneticalterationsintwofirstdegreerelativeswithappendiceallowgrademucinouscarcinomaperitonei
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AT armandosardi germlineandsomaticgeneticalterationsintwofirstdegreerelativeswithappendiceallowgrademucinouscarcinomaperitonei
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