MLL2 is required in oocytes for bulk histone 3 lysine 4 trimethylation and transcriptional silencing.

MLL2 is required in oocytes for bulk histone 3 lysine 4 trimethylation and transcriptional silencing.

During gametogenesis and pre-implantation development, the mammalian epigenome is reprogrammed to establish pluripotency in the epiblast. Here we show that the histone 3 lysine 4 (H3K4) methyltransferase, MLL2, controls most of the promoter-specific chromatin modification, H3K4me3, during oogenesis...

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Bibliographic Details
Main Authors: Claudia V Andreu-Vieyra, Ruihong Chen, Julio E Agno, Stefan Glaser, Konstantinos Anastassiadis, A Francis Stewart, Martin M Matzuk
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-08-01
Series:PLoS Biology
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20808952/?tool=EBI

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