Application value of Serum Hs-CRP, IL-6 and plasma FIB joint detection in COPD

• Main Authors: Feng Ji, Ming-Kun Ge, Jian Ye
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2016-11-01
• Series: Journal of Hainan Medical University
• Subjects: COPD; High sensitivity C-reactive protein; IL-6; Fibrinogen
• Online Access: http://www.hnykdxxb.com/PDF/201622/17.pdf
• ISSN: 1007-1237; 1007-1237

Objective: To discuss the application value of High sensitivity C-reactive protein (Hs-CRP), interleukin-6 (IL-6) and fibrinogen (FIB) joint detection in chronic obstructive pulmonary disease (COPD). Methods: A total of 181 COPD cases were divided to be COPD stable phase group (65 cases) and COPD acute exacerbation phase group (116 cases) per the course of disease. COPD acute exacerbation phase group was classified into grade I (39 cases), grade II (43 cases) and grade III (34 cases) based on pulmonary function. Then survival group (87 cases) and death group (29 cases) were divided based on illness transition. Meanwhile, 80 cases of healthy people at the same phase were set to be healthy group. Differences in levels of Serum hs-CRP, IL-6 and FIB in these groups were analyzed, and according to these indexes, prognostic potency of COPD acute exacerbation phase could be evaluated. Results: Difference in serum hs-CRP, IL-6 and FIB levels in COPD stable phase group, COPD acute exacerbation phase group and healthy group were statistical significant (P<0.05). both for healthy group <COPD stable phase group < COPD acute exacerbation phase group. Difference in serum hs-CRP, IL-6 and FIB levels in grade I, II, III of pulmonary function in the COPD acute exacerbation phase group were statistical significant (P<0.05) both for grade 1 < grade 2 < grade 3. Result of person analyzing showed significant positive correlation on grading of pulmonary function and serum hs-CRP, IL-6 and FIB levels, the correlation coefficient was 0.573. Differences of hs-CRP, IL-6 and FIB levels between survival group and death group were statistical significant. Serum hs-CRP, IL-6 and FIB levels were utilized respectively to evaluate area under curve of receiver operating characteristic in prognostic COPD acute exacerbation phase group, namely, 0.836, 0.815, 0.776. Sensitivities of “death”, which was evaluated by the various indexes, respectively showed as: 72.41%, 65.51% and 75.86%; Specificities were 80.46%, 83.91%, 79.31%; Accuracies were 93.10%, 95.40%, 94.83%. Conclusions: COPD illness evolution and severity could be reflected by serum hs-CRP, IL-6 and plasma FIB all in some extent, the joint detection could be a reference on prognostic evaluation.