Hsp90 blockers inhibit adipocyte differentiation and fat mass accumulation.

Hsp90 blockers inhibit adipocyte differentiation and fat mass accumulation.

Geldanamycin derivatives are benzoquinone ansamycin antibiotics that bind to Hsp90 and alter its function. The alteration of Hsp90 activity limits some cellular hormonal responses by inhibiting nuclear receptors activation. The nuclear receptors activity, such as PPARγ, the mineralocorticoid and glu...

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Bibliographic Details
Main Authors: Sébastien Desarzens, Wan-Hui Liao, Caterina Mammi, Massimiliano Caprio, Nourdine Faresse
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3976389?pdf=render

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