Long term adaptation of a microbial population to a permanent metabolic constraint: overcoming thymineless death by experimental evolution of <it>Escherichia coli</it>

<p>Abstract</p> <p>Background</p> <p>To maintain populations of microbial cells under controlled conditions of growth and environment for an indefinite duration is a prerequisite for experimentally evolving natural isolates of wild-type species or recombinant strains. T...

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Bibliographic Details
Main Authors: Mutzel Rupert, Bellalou Jacques, de Crécy-Lagard Valérie A, Marlière Philippe
Format: Article
Language:English
Published: BMC 2001-11-01
Series:BMC Biotechnology
Online Access:http://www.biomedcentral.com/1472-6750/1/10