Folic acid prevents cardiac dysfunction and reduces myocardial fibrosis in a mouse model of high-fat diet-induced obesity

Folic acid prevents cardiac dysfunction and reduces myocardial fibrosis in a mouse model of high-fat diet-induced obesity

Abstract Background Folic acid (FA) is an antioxidant that can reduce reactive oxygen species generation and can blunt cardiac dysfunction during ischemia. We hypothesized that FA supplementation prevents cardiac fibrosis and cardiac dysfunction induced by obesity. Methods Six-week-old C57BL6/J mice...

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Bibliographic Details
Main Authors: Wei Li, Renqiao Tang, Shengrong Ouyang, Feifei Ma, Zhuo Liu, Jianxin Wu
Format: Article
Language:English
Published: BMC 2017-11-01
Series:Nutrition & Metabolism
Subjects:
High-fat diet
Myocardial fibrosis
Oxidative stress
Folic acid
Cardiac function
Online Access:http://link.springer.com/article/10.1186/s12986-017-0224-0

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